Wu Y, Wong C, Chiles E, Mellinger A., Bae H, Jung S, Peterson T, Wang J, Negrete M, Huang Q, Wang L, Jang C, Muddiman D, Su X, Williamson I, Shen X. (2022) "Glycerate Production from Intestinal Fructose Metabolism Elevated by Dietary Fat Induces Glucose Intolerance Through β-cell Damage". Cell Metabolism (2022): accepted
Bose S, Huang Q, Ma Y, Wang L, Rivera G, Ouyang Y, Whitaker R, Gibson R, Kontos C, Berchuck A, Previs R, Shen X. (2022) "G6PD Inhibition Sensitizes Ovarian Cancer Cells to Oxidative Stress in the Metastatic Omental Microenvironment". Cell Report (2022): accepted
Ding S, Hsu C, Wang Z, Natesh NR, Millen R, Negrete M, Giroux N, Rivera GO, Dohlman A, Bose S, Rotstein T, Spiller K, Yeung A, Sun Z, Jiang C, Xi R, Wilkin B, Randon PM, Williamson I, Nelson DA, Delubac D, Oh S, Rupprecht G, Isaacs J, Jia J, Chen C, Shen JP, Kopetz S, McCall S, Smith A, Gjorevski N, Walz AC, Antonia S, Marrer-Berger E, Clevers H, Hsu D, Shen X. (2022) "Patient-derived micro-organospheres enable clinical precision oncology". Cell Stem Cell (2022): https://www.sciencedirect.com/science/article/abs/pii/S193459092200159X?
Li M, Beaumont N, Ma C, Rojas J, Vu T, Harlacher M, O'Connell G, Gessner RC, Kilian H, Kasatkina L, Chen Y, Huang Q, Shen X, Lovell JF, Verkhusha VV, Czernuszewicz T, Yao J. (2022) "Three-dimensional Deep-tissue Functional and Molecular Imaging by Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT)". IEEE Trans Med Imaging (2022): https://ieeexplore.ieee.org/document/9760438
Giroux NS, Ding S, McClain MT, Burke TW, Petzold E, Chung HA, Rivera GO, Wang E, Xi R, Bose S, Rotstein T, Nicholson BP, Chen T, Henao R, Sempowski GD, Denny TN, De Ussel MI, Satterwhite LL, Ko ER, Ginsburg GS, Kraft BD, Tsalik EL, Shen X, Woods C. (2022) "Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion". Res Sq. (2022): https://www.researchsquare.com/article/rs-1479864/v1
Naqvi I, Giroux N, Olson L, Morrison SA, Llanga T, Akinade TO, Zhu Y, Zhong Y, Bose S, Arvai S, Abramson K, Chen L, Que L, Kraft B, Shen X, Lee J, Leong KW, Nair SK, Sullenger B. (2022) "DAMPs/PAMPs induce monocytic TLR activation and tolerance in COVID-19 patients; nucleic acid binding scavengers can counteract such TLR agonists". Biomaterials. (2022): https://www.sciencedirect.com/science/article/pii/S0142961222000321?
Artola-Borán M, Fallegger A, Priola M, Jeske R, Waterboer T, Dohlman AB, Shen X, Wild S, He J, Levesque MP, Yousefi S, Simon HU, Cheng PF, Müller A. (2022) "Mycobacterial infection aggravates Helicobacter pylori-induced gastric preneoplastic pathology by redirection of de novo induced Treg cells". Cell Reports (2022): https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00080-8?
Kadur Lakshminarasimha Murthy P, Xi R, Arguijo D, Everitt JI, Kocak DD, Kobayashi Y, Bozec A, Vicent S, Ding S, Crawford GE, Hsu D, Tata PR, Reddy T, Shen X. (2022) "Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity". Developmental Cell (2022): https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00006-5?
Micah T. McClain, Florica J. Constantine, Ricardo Henao, Yiling Liu, Ephraim L. Tsalik, Ephraim L. Tsalik, Ephraim L. Tsalik, Thomas W. Burke, Julie M. Steinbrink, Julie M. Steinbrink, Elizabeth Petzold, Bradly P. Nicholson, Robert Rolfe, Bryan D. Kraft, Bryan D. Kraft, Bryan D. Kraft, Matthew S. Kelly, Daniel R. Saban, Chen Yu, Xiling Shen, Emily M. Ko, Gregory D. Sempowski, Thomas N. Denny, Geoffrey S. Ginsburg, Christopher W. Woods, Christopher W. Woods, Christopher W. Woods (2021) "Dysregulated transcriptional responses to SARS-CoV-2 in the periphery". Nature Communications (2021): https://www.scilit.net/article/0ad08a958bee162b6554122632054272?
Anders B. Dohlman, Diana Arguijo Mendoza, Shengli Ding, Michael Gao, Holly Dressman, Iliyan D. Iliev, Steven M. Lipkin, Xiling Shen. (2021) "The cancer microbiome atlas: a pan-cancer comparative analysis to distinguish tissue-resident microbiota from contaminants". Cell Host & Microbe (2021): https://www.sciencedirect.com/science/article/abs/pii/S1931312820306636
Liuyang Wang, Thomas J Balmat, Alejandro L Antonia, Florica J Constantine, Ricardo Henao, Thomas W Burke, Andy Ingham, Micah T McClain, Micah T McClain, Micah T McClain, Ephraim L Tsalik, Emily R Ko, Emily R Ko, Geoffrey S Ginsburg, Mark R DeLong, Xiling Shen, Christopher W Woods, Christopher W Woods, Christopher W Woods, Elizabeth R Hauser, Elizabeth R Hauser, Dennis C Ko (2021) "An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility". Genome Medicine (2021): https://www.ncbi.nlm.nih.gov/pubmed/34001247
Samaneh K. Sarvestani, Steven Signs, Bo Hu, Yunku Yeu, Hao Feng, Ying Ni, David R. Hill, Robert C. Fisher, Sylvain Ferrandon, Reece K. DeHaan, Jennifer Stiene, Michael Cruise, Tae Hyun Hwang, Xiling Shen, Jason R. Spence, Emina H. Huang, Emina H. Huang (2021) "Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity". Nature Communications (2021): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801686/
Chen Yu, Sejiro Littleton, Nicholas S. Giroux, Rose Mathew, Shengli Ding, Joan Kalnitsky, Yuchen Yang, Elizabeth Petzold, Hong A. Chung, Grecia O. Rivera, Tomer Rotstein, Rui Xi, Emily R. Ko, Emily R. Ko, Ephraim L. Tsalik, Ephraim L. Tsalik, Ephraim L. Tsalik, Gregory D. Sempowski, Thomas N. Denny, Thomas W. Burke, Micah T. McClain, Micah T. McClain, Micah T. McClain, Christopher W. Woods, Xiling Shen, Daniel R. Saban (2021) "Mucosal Associated Invariant T (MAIT) Cell Responses Differ by Sex in COVID-19". Med (New York, N.Y.) (2021): https://www.sciencedirect.com/science/article/pii/S2666634021001574
Qiang Huang, Qiang Huang, Aliesha Garrett, Shree Bose, Stephanie Blocker, Anne C. Rios, Hans Clevers, Xiling Shen (2021) "The Frontier of Live Tissue Imaging Across Space and Time". Cell Stem Cell (2021): https://www.sciencedirect.com/science/article/pii/S1934590921000606
Zhuojun Dai, Xiaoyu Yang, Feilun Wu, Lihua Wang, Kun Xiang, Pengcheng Li, Qingqing Lv, Jinhui Tang, Anders Dohlman, Lei Dai, Xiling Shen, Lingchong You (2021) "Living fabrication of functional semi-interpenetrating polymeric materials". Nature Communications (2021): https://www.nature.com/articles/s41467-021-23812-7
Zhaohui Wang, Emilio Cortes-Sanchez, Chieh-Hsiang Yang, Daniel Nelson, Daniel Delubac, Shiaowen David Hsu, Alana Welm, Xiling Shen (2021) "Micro-organospheres: An automated patient-derived model platform for rapid drug screening of breast cancer". Journal of Clinical Oncology (2021): https://ascopubs.org/doi/abs/10.1200/JCO.2021.39.15_suppl.e12628
Lihua Wang, Ergang Wang, Jorge Prado Balcazar, Zhenzhen Wu, Kun Xiang, Yi Wang, Qiang Huang, Marcos Negrete, Kai Yuan Chen, Wei Li, Yujie Fu, Anders Dohlman, Robert Mines, Liwen Zhang, Yoshihiko Kobayashi, Tianyi Chen, Guizhi Shi, John Paul Shen, Scott Kopetz, Purushothama Rao Tata, Victor Moreno, Charles Gersbach, Gregory Crawford, David Hsu, Emina Huang, Pengcheng Bu, Xiling Shen (2021) "Chromatin Remodeling of Colorectal Cancer Liver Metastasis is Mediated by an HGF-PU.1-DPP4 Axis". Advanced Science (2021): https://www.ncbi.nlm.nih.gov/pubmed/34378358
Richard C. Davis, Xiang Li, Yuemei Xu, Zehan Wang, Nao Souma, Gina Sotolongo, Jonathan Bell, Matthew Ellis, David Howell, Xiling Shen, Kyle Lafata, Laura Barisoni (2021) "Deep Learning Segmentation of Glomeruli on Kidney Donor Frozen Sections". medRxiv (2021): https://www.medrxiv.org/content/10.1101/2021.09.16.21263707v1
Naveen Natesh, Shengli Ding, Golshid Sanati, Shiaowen David Hsu, Scott Joseph Antonia, Xiling Shen (2021) "A micro-organosphere potency assay for adoptive T-cell therapy". Journal of Clinical Oncology (2021): https://ascopubs.org/doi/abs/10.1200/JCO.2021.39.15_suppl.e15027
Aliesha Garrett, Nikolai Rakhilin, Nian Wang, Jennifer McKey, Gary Cofer, Robert Bj Anderson, Blanche Capel, G Allan Johnson, Xiling Shen (2021) "Mapping the peripheral nervous system in the whole mouse via compressed sensing tractography". Journal of Neural Engineering (2021): https://www.ncbi.nlm.nih.gov/pubmed/33979784
Shengli Ding, Zhaohui Wang, Marcos Negrete Obando, Grecia rivera Palomino, Tomer Rotstein, Ian Williamson, Shiaowen David Hsu, Xiling Shen (2021) "Patient-derived micro-organospheres recapitulate tumor microenvironment and heterogeneity for precision oncology". Journal of Clinical Oncology (2021): https://ascopubs.org/doi/abs/10.1200/JCO.2021.39.15_suppl.3076
Z. Wang, E. Cortes-Sanchez, C-H. Yang, D. Nelson, C. Keating, A. Smith, D. Hsu, B. Welm, A. Welm, X. Shen (2021) "1149P An automated platform for rapid drug screening in patient-derived micro-organospheres". Annals of Oncology (2021): https://www.annalsofoncology.org/article/S0923-7534(21)03019-2/fulltext
Aliesha Danielle O'Raw, Nikolai Rakhilin, Nian Wang, Jennifer McKey, Gary Cofer, Robert Bj Anderson, Blanche Capel, G Allan Johnson, Xiling Shen Author response for "Mapping the peripheral nervous system in the whole mouse via compressed sensing tractography" (2021)
Ian A. Williamson, Chi Wut Wong, Yanru Wu, Xiaoyang Su, John F. Rawls, Xiling Shen (2021) "713c Dietary Fat Increases Intestinal Fructose Conversion to Glycerate that Accumlates in Circulation, Driving Glucose Intolerance". Gastroenterology (2021): https://www.gastrojournal.org/article/S0016-5085(21)03147-4/fulltext
Qiang Huang, Qiang Huang, Malkiel A. Cohen, Fernando C. Alsina, Garth Devlin, Aliesha Garrett, Jennifer McKey, Patrick Havlik, Nikolai Rakhilin, Ergang Wang, Kun Xiang, Parker Mathews, Lihua Wang, Cheryl Bock, Victor Ruthig, Yi Wang, Marcos Negrete, Chi Wut Wong, Preetish K. L. Murthy, Shupei Zhang, Andrea R. Daniel, David G. Kirsch, Yubin Kang, Blanche Capel, Aravind Asokan, Debra L. Silver, Rudolf Jaenisch, Xiling Shen (2020) "Intravital imaging of mouse embryos". Science (2020): https://www.scilit.net/article/628f5a88bfbbd97e0030215617833abd
Tianyi Chen, Sehhoon Oh, Simon Gregory, Xiling Shen, Anna Mae Diehl (2020) "Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration". JCI insight (2020): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710279
Anil Dangi, Naveen R. Natesh, Irma Husain, Zhicheng Ji, Laura Barisoni, Jean Kwun, Xiling Shen, Edward B. Thorp, Xunrong Luo (2020) "Single cell transcriptomics of mouse kidney transplants reveals a myeloid cell pathway for transplant rejection". JCI insight (2020): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605544
Michael Bauer, Zuzana Nascakova, Zuzana Nascakova, Anca-Irina Mihai, Phil F. Cheng, Mitchell P. Levesque, Simon Lampart, Robert Hurwitz, Lennart Pfannkuch, Jana Dobrovolna, Melanie Jacobs, Sina Bartfeld, Anders Dohlman, Xiling Shen, Alevtina A. Gall, Nina R. Salama, Antonia Töpfer, Achim Weber, Thomas F. Meyer, Pavel Janscak, Pavel Janscak, Anne Müller (2020) "The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress". Nature Communications (2020): https://www.zora.uzh.ch/id/eprint/190954/
Samaneh Kamali Sarvestani, Reece K. DeHaan, Paula G. Miller, Shree Bose, Xiling Shen, Michael L. Shuler, Emina H. Huang (2020) "A Tissue Engineering Approach to Metastatic Colon Cancer". iScience (2020): https://www.sciencedirect.com/science/article/pii/S2589004220309160
Erdem Altunel, Roham S. Roghani, Kai-Yuan Chen, So Young Kim, Shannon McCall, Kathryn E. Ware, Xiling Shen, Jason A. Somarelli, David S. Hsu (2020) "Development of a precision medicine pipeline to identify personalized treatments for colorectal cancer". BMC Cancer (2020): https://www.researchsquare.com/article/rs-18273/v1
Liuyang Wang, Thomas J Balmat, Alejandro L Antonia, Florica J Constantine, Ricardo Henao, Thomas W Burke, Andy Ingham, Micah T McClain, Micah T McClain, Micah T McClain, Ephraim L Tsalik, Emily R Ko, Emily R Ko, Geoffrey S Ginsburg, Mark R DeLong, Xiling Shen, Christopher W Woods, Christopher W Woods, Christopher W Woods, Elizabeth R Hauser, Elizabeth R Hauser, Dennis C Ko (2020) "An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility". medRxiv (2020): https://www.ncbi.nlm.nih.gov/pubmed/33398303
Nicholas S. Giroux, Shengli Ding, Micah T. McClain, Thomas W. Burke, Elizabeth W. Petzold, Hong A. Chung, Grecia R. Palomino, Ergang Wang, Rui Xi, Shree Bose, Tomer Rotstein, Bradly P. Nicholson, Tianyi Chen, Ricardo Henao, Gregory D. Sempowski, Thomas N. Denny, Emily R. Ko, Geoffrey S. Ginsburg, Bryan D. Kraft, Ephraim L. Tsalik, Christopher W. Woods, Christopher W. Woods, Christopher W. Woods, Xiling Shen (2020) "Chromatin remodeling in peripheral blood cells reflects COVID-19 symptom severity" bioRxiv (2020): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724678
Jason A. Somarelli, Roham Salman Roghani, Ali Sanjari Moghaddam, Beatrice C. Thomas, Gabrielle Rupprecht, Kathryn E. Ware, Erdem Altunel, John B. Mantyh, So Young Kim, Shannon J. McCall, Xiling Shen, Christopher R. Mantyh, David S. Hsu (2020) "A Precision Medicine Drug Discovery Pipeline Identifies Combined CDK2 and 9 Inhibition as a Novel Therapeutic Strategy in Colorectal Cancer". Molecular Cancer Therapeutics (2020) https://www.scilit.net/article/4e580b576942f76f67fe5a8c697d9ef0
Chen Yu, Sejiro Littleton, Nicholas Giroux, Rose Mathew, Shengli Ding, Joan Kalnitsky, Elizabeth W. Petzold, Hong Chung, Grecia Rivera Palomino, Tomer Rotstein, Rui Xi, Emily R. Ko, Emily R. Ko, Ephraim L. Tsalik, Ephraim L. Tsalik, Ephraim L. Tsalik, Gregory D. Sempowski, Thomas N. Denny, Thomas W. Burke, Micah T. McClain, Micah T. McClain, Micah T. McClain, Christopher W. Woods, Xiling Shen, Daniel R. Saban (2020) "Mucosal Associated Invariant T (MAIT) Cell Responses Differ by Sex in COVID-19". bioRxiv (2020) https://www.biorxiv.org/content/10.1101/2020.12.01.407148v1
Xiling Shen, Shengli Ding, Holly Dressman, Anders B. Dohlman, Michael Gao, Diana Arguijo-Mendoza, Steven M. Lipkin, Iliyan D. Iliev (2020) "Data from: The Cancer Microbiome Atlas (TCMA): A Pan-Cancer Comparative Analysis to Distinguish Organ-Associated Microbiota from Equiprevalent Contaminants". Research Data Repository, Duke University (2020): https://dx.doi.org/10.7924/r4rn36833
Nikolai Rakhilin, Aliesha Garrett, Chi-Yong Eom, Katherine Ramos Chavez, David M. Small, Andrea R. Daniel, Melanie M. Kaelberer, Menansili A. Mejooli, Qiang Huang, Shengli Ding, David G. Kirsch, Diego V. Bohórquez, Nozomi Nishimura, Bradley B. Barth, Xiling Shen (2019) "An intravital window to image the colon in real time". Nature Communications (2019): https://www.ncbi.nlm.nih.gov/pubmed/31827103
Anders B Dohlman, Xiling Shen (2019) "Mapping the microbial interactome: Statistical and experimental approaches for microbiome network inference". Experimental Biology and Medicine (2019): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547001
Yitian Xu, Lu Huang, Jonathan L. Kirschman, Daryll A. Vanover, Pooja M. Tiwari, Philip J. Santangelo, Xiling Shen, Xiling Shen, David G. Russell (2019) "Exploitation of Synthetic mRNA To Drive Immune Effector Cell Recruitment and Functional Reprogramming In Vivo". Journal of Immunology (2019): https://www.ncbi.nlm.nih.gov/pubmed/30541883
Rui Xi, Preetish Kadur Lakshminarasimha Murthy, Preetish Kadur Lakshminarasimha Murthy, Kuei Ling Tung, Kuei Ling Tung, Cynthia D. Guy, Ji Wan, Feng Li, Zhuo Wang, Xiaodong Li, Anastasia Varanko, Nikolai Rakhilin, Nikolai Rakhilin, Yongning Xin, Botao Liu, Shu Bing Qian, Lishan Su, Yan Han, Xiling Shen (2019) "SENP3-mediated host defense response contains HBV replication and restores protein synthesis". PLOS ONE (2019): https://www.ncbi.nlm.nih.gov/pubmed/30640896
Huanhuan Joyce Chen, Zhubo Wei, Jian Sun, Asmita Bhattacharya, David J. Savage, Rita Serda, Yuri Mackeyev, Steven A. Curley, Pengcheng Bu, Lihua Wang, Shuibing Chen, Leona Cohen-Gould, Emina Huang, Xiling Shen, Steven M. Lipkin, Neal G. Copeland, Nancy A. Jenkins, Michael L. Shuler (2019) "Author Correction: A recellularized human colon model identifies cancer driver genes". Nature Biotechnology (2019): https://www.ncbi.nlm.nih.gov/pubmed/31160724
Kuei-Ling Tung, Kuei-Ling Tung, Kai-Yuan Chen, Marcos Negrete, Tianyi Chen, Alexias Safi, Abed Alhalim Aljamal, Lingyun Song, Gregory E. Crawford, Shengli Ding, David S. Hsu, Xiling Shen (2019) "Integrated chromatin and transcriptomic profiling of patient-derived colon cancer organoids identifies personalized drug targets to overcome oxaliplatin resistance". Genes and Diseases (2019): https://www.scienceopen.com/document?vid=899acac1-d18e-4eb1-91de-2922b25cee3e
Jiahn Choi, Nikolai Rakhilin, Poornima Gadamsetty, Daniel J. Joe, Tahmineh Tabrizian, Steven M. Lipkin, Derek M. Huffman, Xiling Shen, Nozomi Nishimura (2019) "Author Correction: Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by aging". Scientific Reports (2019): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768855
Robert Mines, Kai-Yuan Chen, Xiling Shen (2019) "Agent-Based Modelling to Delineate Spatiotemporal Control Mechanisms of the Stem Cell Niche". Methods of Molecular Biology (2019): https://www.ncbi.nlm.nih.gov/pubmed/31062303
Shen Xiling, Hsu Shiaowen David (2019) "PATIENT SPECIFIC CLINICAL TRIALS AND ASSOCIATED METHODS OF TREATMENT"
Melanie Maya Kaelberer, Kelly L. Buchanan, Marguerita E. Klein, Bradley B. Barth, Marcia M. Montoya, Xiling Shen, Diego V. Bohórquez (2018) "A gut-brain neural circuit for nutrient sensory transduction". Science (2018): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417812/
Pengcheng Bu, Pengcheng Bu, Kai Yuan Chen, Kun Xiang, Christelle Johnson, Scott B. Crown, Nikolai Rakhilin, Nikolai Rakhilin, Yiwei Ai, Lihua Wang, Rui Xi, Inna Astapova, Yan Han, Jiahe Li, Bradley B. Barth, Min Lu, Ziyang Gao, Robert Mines, Liwen Zhang, Mark Herman, David Hsu, Guofang Zhang, Xiling Shen (2018) "Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis". Cell Metabolism (2018): https://www.sciencedirect.com/science/article/pii/S1550413118302444
Yitian Xu, Lihua Wang, Matthew D. Zimmerman, Kai-Yuan Chen, Kai-Yuan Chen, Lu Huang, Dah-Jiun Fu, Firat Kaya, Nikolai Rakhilin, Nikolai Rakhilin, Evgeniya V. Nazarova, Pengcheng Bu, Veronique Dartois, David G. Russell, Xiling Shen, Xiling Shen (2018) "Matrix metalloproteinase inhibitors enhance the efficacy of frontline drugs against Mycobacterium tuberculosis". PLOS Pathogens (2018): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919409
Kai-Yuan Chen, Tara Srinivasan, Christopher Lin, Kuei-Ling Tung, Ziyang Gao, David S. Hsu, Steven M. Lipkin, Xiling Shen (2018) "Single-Cell Transcriptomics Reveals Heterogeneity and Drug Response of Human Colorectal Cancer Organoids". International Conference of the IEEE Engineering in Medicine and Biology Society (2018): https://www.ncbi.nlm.nih.gov/pubmed/30440885
Lihua Wang, Ergang Wang, Yi Wang, Yi Wang, Robert Mines, Kun Xiang, Zhiguo Sun, Gaiting Zhou, Kai-Yuan Chen, Nikolai Rakhilin, Nikolai Rakhilin, Shanshan Chao, Gaoqi Ye, Zhenzhen Wu, Huiwen Yan, Hong Shen, Jeffrey Everitt, Pengcheng Bu, Xiling Shen, Xiling Shen (2018) "miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis". eLife (2018): https://www.ncbi.nlm.nih.gov/pubmed/30543324
Jiahn Choi, Nikolai Rakhilin, Poornima Gadamsetty, Daniel J. Joe, Tahmineh Tabrizian, Steven M. Lipkin, Derek M. Huffman, Xiling Shen, Nozomi Nishimura (2018) "Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by aging". Scientific Reports (2018): https://www.ncbi.nlm.nih.gov/pubmed/30030455
Preetish Kadur Lakshminarasimha Murthy, Preetish Kadur Lakshminarasimha Murthy, Tara Srinivasan, Matthew S Bochter, Rui Xi, Anastasia Kristine Varanko, Kuei-Ling Tung, Kuei-Ling Tung, Fatih Semerci, Keli Xu, Mirjana Maletic-Savatic, Susan E Cole, Xiling Shen, Xiling Shen (2018) "Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis". eLife (2018): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896954
Bradley B Barth, Hsin-I Huang, Gianna E Hammer, Xiling Shen (2018) "Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals". Micromachines (2018): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187697/
Ziyang Gao, Kai-Yuan Chen, Olaf Mueller, Han Zhang, Nikolai Rakhilin, Jiande Chen, Xiling Shen (2018) "Microbiota of Inflammatory Bowel Disease Models". International Conference of the IEEE Engineering in Medicine and Biology Society (2018): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709594/
Lihua Wang, Ergang Wang, Yi Wang, Yi Wang, Robert Mines, Kun Xiang, Zhiguo Sun, Gaiting Zhou, Kai-Yuan Chen, Nikolai Rakhilin, Nikolai Rakhilin, Shanshan Chao, Gaoqi Ye, Zhenzhen Wu, Huiwen Yan, Hong Shen, Jeffrey Everitt, Pengcheng Bu, Xiling Shen, Xiling Shen (2018) "Author response: miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis". eLife (2018)
Robert C. Mines, Anders Dohlman, Sze-Xian Lim, Kuei-Ling Tung, Ergang Wang, Xiling Shen (2018) "Spatial Patterning from an Integrated Wnt/β-catenin and Notch/Delta Gene Circuit". International Conference of the IEEE Engineering in Medicine and Biology Society (2018): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081632
Bradley Barth, Hsin-I Huang, Gianna Hammer, Xiling Shen (2018) "Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals". (2018) https://www.preprints.org/manuscript/201807.0631/v1
Erik A. Zavrel, Michael L. Shuler, Xiling Shen (2018) "A Simple Aspect Ratio Dependent Method of Patterning Microwells for Selective Cell Attachment". 2018 Design of Medical Devices Conference : April 9-12, 2018, Minneapolis, Minnesota, USA. Design of Medical Devices Conference (2018 : Minneapolis, Minn.) (2018): https://www.ncbi.nlm.nih.gov/pubmed/30854173
Preetish Kadur Lakshminarasimha Murthy, Preetish Kadur Lakshminarasimha Murthy, Tara Srinivasan, Matthew S Bochter, Rui Xi, Anastasia Kristine Varanko, Kuei-Ling Tung, Kuei-Ling Tung, Fatih Semerci, Keli Xu, Mirjana Maletic-Savatic, Susan E Cole, Xiling Shen, Xiling Shen (2018) "Author response: Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis". eLife (2018)
Erik A. Zavrel, Xiling Shen (2018) "TOWARD A MICROFLUIDIC IMPLEMENTATION OF A DIGITAL POTENTIOMETER". 2018 Design of Medical Devices Conference : April 9-12, 2018, Minneapolis, Minnesota, USA. Design of Medical Devices Conference (2018 : Minneapolis, Minn.) (2018): https://www.ncbi.nlm.nih.gov/pubmed/30854172
Melanie M. Kaelberer, Kelly Buchanan, Marguerita Klein, Marcia Montoya, Bradley Barth, Xiling Shen, Diego V. Bohórquez (2018) "725 - Sensory Synaptic Transduction from Gut to Brain". Gastroenterology (2018): https://www.gastrojournal.org/article/S0016-5085(18)30915-6/abstract
Christoph S.N. Klose, Tanel Mahlakõiv, Jesper B. Moeller, Jesper B. Moeller, Lucille C. Rankin, Anne Laure Flamar, Hiroki Kabata, Laurel A. Monticelli, Saya Moriyama, Gregory Garbès Putzel, Nikolai Rakhilin, Nikolai Rakhilin, Xiling Shen, Xiling Shen, Evi Kostenis, Gabriele M. König, Takashi Senda, Dustin Carpenter, Donna L. Farber, David Artis (2017) "The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation". Nature (2017): https://www.ncbi.nlm.nih.gov/pubmed/28869965
Subhash Kulkarni, Maria Adelaide Micci, Jenna Leser, Changsik Shin, Shiue Cheng Tang, Ya Yuan Fu, Liansheng Liu, Qian Li, Monalee Saha, Cuiping Li, Grigori Enikolopov, Grigori Enikolopov, Laren Becker, Nikolai Rakhilin, Nikolai Rakhilin, Michael Anderson, Xiling Shen, Xiling Shen, Xinzhong Dong, Manish J. Butte, Hongjun Song, E. Michelle Southard-Smith, Raj P. Kapur, Milena Bogunovic, Pankaj J. Pasricha (2017) "Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis". Proceedings of the National Academy of Sciences of the United States of America (2017): https://www.pnas.org/content/114/18/E3709
Kai-Yuan Chen, Kai-Yuan Chen, Tara Srinivasan, Kuei-Ling Tung, Julio M Belmonte, Lihua Wang, Lihua Wang, Preetish Kadur Lakshminarasimha Murthy, Jiahn Choi, Nikolai Rakhilin, Nikolai Rakhilin, Sarah King, Anastasia Kristine Varanko, Mavee Witherspoon, Nozomi Nishimura, James A Glazier, Steven M Lipkin, Pengcheng Bu, Pengcheng Bu, Xiling Shen, Xiling Shen (2017) "A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal". Molecular Systems Biology (2017): https://www.ncbi.nlm.nih.gov/pubmed/28455349
Yiwei Wang, Dan Huang, Kai Yuan Chen, Min Cui, Weihuan Wang, Xiaoran Huang, Amad Awadellah, Qing Li, Ann Friedman, William W. Xin, Luca Di Martino, Fabio Cominelli, Alexander Miron, Ricky Chan, James G. Fox, Yan Xu, Xiling Shen, Matthew F Kalady, Sanford D Markowitz, Ivan Maillard, John B. Lowe, Wei Xin, Lan Zhou (2017) "Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma". Gastroenterology (2017): https://www.sciencedirect.com/science/article/pii/S0016508516350296
Bradley B Barth, Craig S Henriquez, Warren M Grill, Xiling Shen (2017) "Electrical stimulation of gut motility guided by an in silico model". Journal of Neural Engineering (2017): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724779
Jianjun Yu, Xiaosheng Qin, Yee Meng Chiew, Rui Min, Xiling Shen (2017) "Stochastic Optimization Model for Supporting Urban Drainage Design under Complexity". Journal of Water Resources Planning and Management (2017): https://ascelibrary.org/doi/pdf/10.1061/%28ASCE%29WR.1943-5452.0000806
Jiahn Choi, Nikolai Rakhilin, Poornima Gadamsetty, Daniel J. Joe, Tahmineh Tabrizian, Steven M. Lipkin, Derek M. Huffman, Xiling Shen, Nozomi Nishimura (2017) "Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by aging". bioRxiv (2017): https://www.biorxiv.org/content/10.1101/218685v1
Jiahe Li, Yiwei Ai, Lihua Wang, Pengcheng Bu, Charles C. Sharkey, Qianhui Wu, Brittany Wun, Sweta Roy, Xiling Shen, Michael R. King (2016) "Targeted drug delivery to circulating tumor cells via platelet membrane-functionalized particles". Biomaterials (2016): https://www.sciencedirect.com/science/article/pii/S014296121500856X
Pengcheng Bu, Lihua Wang, Kai-Yuan Chen, Tara Srinivasan, Preetish Kadur Lakshminarasimha Murthy, Kuei-Ling Tung, Anastasia Kristine Varanko, Huanhuan Joyce Chen, Yiwei Ai, Sarah King, Steven M. Lipkin, Xiling Shen (2016) "A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer". Cell Stem Cell (2016): https://www.sciencedirect.com/science/article/pii/S1934590916000072
Lihua Wang, Pengcheng Bu, Pengcheng Bu, Yiwei Ai, Tara Srinivasan, Huanhuan Joyce Chen, Kun Xiang, Steven M Lipkin, Xiling Shen (2016) "A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division". eLife (2016): https://www.ncbi.nlm.nih.gov/pubmed/27077950
Huanhuan Joyce Chen, Zhubo Wei, Jian Sun, Asmita Bhattacharya, David J Savage, Rita Serda, Yuri Mackeyev, Steven A Curley, Pengcheng Bu, Lihua Wang, Shuibing Chen, Leona Cohen-Gould, Emina Huang, Xiling Shen, Steven M Lipkin, Neal G Copeland, Nancy A Jenkins, Michael L Shuler (2016) "A recellularized human colon model identifies cancer driver genes". Nature Biotechnology (2016): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980997
Nikolai Rakhilin, Bradley Barth, Jiahn Choi, Nini L. Muñoz, Subhash Kulkarni, Jason S. Jones, David M. Small, Yu Ting Cheng, Yingqiu Cao, Colleen Lavinka, Edwin Kan, Xinzhong Dong, Xinzhong Dong, Michael Spencer, Pankaj Pasricha, Nozomi Nishimura, Xiling Shen, Xiling Shen (2016) "Simultaneous optical and electrical in vivo analysis of the enteric nervous system". Nature Communications (2016): https://www.ncbi.nlm.nih.gov/pubmed/27270085
Tara Srinivasan, Jewell Walters, Pengcheng Bu, Elaine Bich Than, Kuei Ling Tung, Kai Yuan Chen, Nicole Panarelli, Jeff Milsom, Leonard Augenlicht, Steven M. Lipkin, Xiling Shen, Xiling Shen (2016) "NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer-Initiating Cells". Cancer Research (2016): https://www.ncbi.nlm.nih.gov/pubmed/27197180
Tara Srinivasan, Elaine Bich Than, Pengcheng Bu, Kuei Ling Tung, Kai Yuan Chen, Leonard Augenlicht, Steven M. Lipkin, Xiling Shen, Xiling Shen (2016) "Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells". Scientific Reports (2016): https://www.ncbi.nlm.nih.gov/pubmed/27181744
Daniel J. Joe, Jeonghyun Hwang, Christelle Johnson, Ho-Young Cha, Jo-Won Lee, Xiling Shen, Michael G. Spencer, Sandip Tiwari, Moonkyung Kim (2016) "Surface Functionalized Graphene Biosensor on Sapphire for Cancer Cell Detection". Journal of Nanoscience and Nanotechnology (2016): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724034
Yingqiu Cao, Nikolai Rakhilin, Philip H. Gordon, Xiling Shen, Edwin C. Kan (2016) "A real-time spike classification method based on dynamic time warping for extracellular enteric neural recording with large waveform variability". Journal of Neuroscience Methods (2016): https://www.sciencedirect.com/science/article/pii/S016502701500446X
Daniel E Rothschild, Tara Srinivasan, Linette A Aponte-Santiago, Xiling Shen, Irving C Allen (2016) "The Ex Vivo Culture and Pattern Recognition Receptor Stimulation of Mouse Intestinal Organoids". Journal of Visualized Experiments (2016): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927701
Yiwei Wang, Dan Huang, Kai-Yuan Chen, Min Cui, Weihuan Wang, Xiaoran Huang, Amad Awadellah, Qing Li, Ann Friedman, William W. Xin, Luca Di Martino, Fabio Cominelli, Alex Miron, Ricky Chan, James G. Fox, Yan Xu, Xiling Shen, Mathew F. Kalady, Sanford Markowitz, Ivan Maillard, John B. Lowe, Wei Xin, Lan Zhou (2016) "Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma". PMC (2016): https://dspace.mit.edu/openaccess-disseminate/1721.1/117652
Lihua Wang, Pengcheng Bu, Pengcheng Bu, Yiwei Ai, Tara Srinivasan, Huanhuan Joyce Chen, Kun Xiang, Steven M Lipkin, Xiling Shen (2016) "Author response: A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division". eLife (2016)
Shengyi Sun, Guojun Shi, Haibo Sha, Yewei Ji, Xuemei Han, Xin Shu, Hongming Ma, Takamasa Inoue, Beixue Gao, Hana Kim, Pengcheng Bu, Robert D. Guber, Xiling Shen, Xiling Shen, Ann Hwee Lee, Takao Iwawaki, Adrienne W. Paton, James C. Paton, Deyu Fang, Billy Tsai, John R. Yates, Haoquan Wu, Sander Kersten, Qiaoming Long, Gerald E. Duhamel, Kenneth W. Simpson, Ling Qi (2015) "IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation". Nature Cell Biology (2015): https://www.scholars.northwestern.edu/en/publications/ire1%CE%B1-is-an-endogenous-substrate-of-endoplasmic-reticulum-associa
Pengcheng Bu, Lihua Wang, Kai-Yuan Chen, Nikolai Rakhilin, Jian Sun, Adria Closa, Kuei-Ling Tung, Sarah King, Anastasia Kristine Varanko, Yitian Xu, Joyce Huan Chen, Amelia S Zessin, James Shealy, Bethany Cummings, David Hsu, Steven M Lipkin, Victor Moreno, Zeynep H Gümüş, Xiling Shen (2015) "miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β". Nature Communications (2015): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399006/
Huanhuan Joyce Chen, Jian Sun, Zhiliang Huang, Harry Hou, Myra Arcilla, Nikolai Rakhilin, Daniel J Joe, Jiahn Choi, Poornima Gadamsetty, Jeff Milsom, Govind Nandakumar, Randy Longman, Xi Kathy Zhou, Robert Edwards, Jonlin Chen, Kai Yuan Chen, Pengcheng Bu, Lihua Wang, Yitian Xu, Robert Munroe, Christian Abratte, Andrew D Miller, Zeynep H Gümüş, Michael Shuler, Nozomi Nishimura, Winfried Edelmann, Xiling Shen, Steven M Lipkin (2015) "Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting". Nature Biotechnology (2015): https://www.ncbi.nlm.nih.gov/pubmed/26006007
Feng Yating, Si Gaofeng, Shen Xiling, Wen Rujun (2015) "Power transmission line tower detects with dismantling ladder". (2015)
Feng Yating, Si Gaofeng, Shen Xiling, Wen Rujun (2015) "Detachable ladder for electric power pylon detection". (2015)
Steven M. Lipkin, Huanhuan Joyce Chen, Jian Sun, Zhiliang Huang, Harry Hou, Myra Arcilla, Nikolai Rakhilin, Daniel Joe, Jiahn Choi, Poornima Gadamsetty, Jeff Milsom, Govind Nandakumar, Randy Longman, Kathy Zhou, Robert Edwards, Kai Yuan Chen, Pengcheng Bu, Lihua Wang, Yitian Xu, Robert Munroe, Christian Abratte, Andrew Miller, Zeynep Gümüş, Michael Shuler, Nozomi Nishimura, Winfried Edelmann, Xiling Shen (2015) "Abstract 2891: Chemokine-targeted models of human orthotopic colorectal cancer in immunocompetant mice". Cancer Research (2015): https://cancerres.aacrjournals.org/content/75/15_Supplement/2891
Jiahn Choi, Daniel J. Joe, Poornima Gadamsetty, Nikolai Rakhilin, Pengcheng Bu, Steven Lipkin, Xiling Shen, Nozomi Nishimura (2015) "Understanding the Dynamics of the Stem Cell Niche in the Small Intestine with Femtosecond Laser Photodisruption". Frontiers in Optics (2015): https://www.osapublishing.org/abstract.cfm?uri=FiO-2015-FTu2D.2
Kai-Yuan Chen, Xiaojing Liu, Pengcheng Bu, Chieh-Sheng Lin, Nikolai Rakhilin, Jason W. Locasale, Xiling Shen (2014) "A metabolic signature of colon cancer initiating cells". International Conference of the IEEE Engineering in Medicine and Biology Society (2014): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302416/
Zhao Qu, Xiling Shen, Kun Ding (2014) "Comparative analysis on technologies between Chinese and American large-sized oil companies based on patentometrics". Journal of Scientific Research (2014): https://www.jscires.org/article/75
Huanhuan Joyce Chen, Jian Sun, Harry Hou, Winfried Edelmann, Xiling Shen, Steven M. Lipkin (2014) "Abstract 3118: Chemokine-targeted colorectal cancer: improved models of human primary tumor formation, liver metastasis and chemoresistance". Cancer Research (2014): https://cancerres.aacrjournals.org/content/74/19_Supplement/3118
Christelle Johnson, Kai-Yuan Chen, Xiaojing Liu, Pengcheng Bu, Jason Locasale, Xiling Shen (2014) "A metabolic signature of colon cancer initiating cells". Cancer and Metabolism (2014): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072946/
Kai-Yuan Chen, Danial J. Joe, James B. Shealy, Bruce R. Land, Xiling Shen (2014) "A bio-inspired spatial patterning circuit". International Conference of the IEEE Engineering in Medicine and Biology Society (2014): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304701
Pengcheng Bu, Kai-Yuan Chen, Joyce Huan Chen, Lihua Wang, Jewell Walters, Yong Jun Shin, Julian P. Goerger, Jian Sun, Mavee Witherspoon, Nikolai Rakhilin, Jiahe Li, Herman Yang, Jeff Milsom, Sang Lee, Warren Zipfel, Moonsoo M. Jin, Zeynep H. Gümüş, Steven M. Lipkin, Xiling Shen (2013) "A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells". Cell Stem Cell (2013): https://www.sciencedirect.com/science/article/pii/S1934590913000970
Yong-Jun Shin, Kai-Yuan Chen, Ali H Sayed, Brandon Hencey, Xiling Shen (2013) "Post-translational regulation enables robust p53 regulation". BMC Systems Biology (2013): https://www.ncbi.nlm.nih.gov/pubmed/23992617
Jiahe Li, Pengcheng Bu, Kai-Yuan Chen, Xiling Shen (2013) "Spatial perturbation with synthetic protein scaffold reveals robustness of asymmetric cell division". Journal of Biomedical Science and Engineering (2013): https://www.scirp.org/journal/PaperInformation.aspx?PaperID=28256
Huanhuan Chen, Steven M. Lipkin, Xiling Shen (2013) "Mammal with an orthotopic tumor capable of metastasis, a method of making and a method of using".(2013): https://www.freepatentsonline.com/9681647.html
Xi-ling Shen, Jia Zhao, Xiao-li Zhang, Kun Tian (2013) "Ultrasonographic features of aortic dissection". Central Plains Medical Journal (2013)
Huanhuan Joyce Chen, Robert Edwards, Serena Tucci, Pengcheng Bu, Jeff Milsom, Sang Lee, Winfried Edelmann, Zeynep H. Gümüs, Xiling Shen, Steven Lipkin (2012) "Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis". Journal of Clinical Investigation (2012): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428084
Yong-Jun Shin, Ali H. Sayed, Xiling Shen (2012) "Using an adaptive gene network model for self-organizing multicellular behavior". International Conference of the IEEE Engineering in Medicine and Biology Society (2012): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310473/
Huanhuan Chen, Serena Tucci, Zeynep Gümüs, Xiling Shen, Steven M. Lipkin (2012) "Abstract 5207: The chemokine 25 and chemokine receptor 9 axis suppresses colon cancer invasion and metastasis". Cancer Research (2012): https://cancerres.aacrjournals.org/content/72/8_Supplement/5207
Yong-Jun Shin, Ali H. Sayed, Brandon Hencey, Xiling Shen (2012) "Feedback Control Theory Reveals Tradeoff between Robustness and Stability in the p53-MDM2 Network". 2012 q-bio Conference, Santa Fe, NM (2012): https://infoscience.epfl.ch/record/233402/files/Shin_YongJun_Talk.pdf
Xi-ling Shen, Jia Zhao, Xiao-li Zhang, Pu-nan Li, Kun Tian (2012) "Application of three-dimensional SRI to study myocardial PSS on the significance of ischemic cardiomyopathy". Central Plains Medical Journal (2012)
Yong-Jun Shin, Brandon Hencey, Steven M. Lipkin, Xiling Shen (2011) 'Frequency domain analysis reveals external periodic fluctuations can generate sustained p53 oscillation". PLOS ONE (2011): https://www.ncbi.nlm.nih.gov/pubmed/21829536
Yong-Jun Shin, Steven M. Lipkin, Brandon Hencey, Xiling Shen (2011) "Disturbance Rejection Helps Modulate the p53 Oscillation". ASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control, Volume 2 (2011): https://proceedings.asmedigitalcollection.asme.org/proceeding.aspx?articleid=1638828
Xiling Shen (2011) "Silencing trumpet capable of being used for abreacting".
Douglas Densmore, Mark Horowitz, Smita Krishnaswamy, Xiling Shen, Adam Arkin, Erik Winfree, Chris Voigt (2011) "Joint DAC/IWBDA special session design and synthesis of biological circuits". Design Automation Conference (2011): https://ieeexplore.ieee.org/document/5981926/
Xiling Shen (2011) "Test paper sorting box".
Meng How Tan, Jennifer B. Kozdon, Xiling Shen, Lucy Shapiro, Harley H. McAdams (2010) "An essential transcription factor, SciP, enhances robustness of Caulobacter cell cycle regulation". Proceedings of the National Academy of Sciences of the United States of America (2010): https://www.pnas.org/content/107/44/18985
Shen X, Collier J, Dill D, Shapiro L, Horowitz M, McAdams H. (2008) "Architecture and inherent robustness of a bacterial cell-cycle control system". Proceedings of the National Academy of Sciences (2005): https://www.pnas.org/doi/abs/10.1073/pnas.0805258105